1-Benzothien-7-ylboronic acid → HCID 10070752, compound

HRID 1180298Notes

Reaction equation

HRID 1180298 reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:9]2[N:13]3[CH:14]=[CH:15][C:16]([C:19]([OH:22])([CH3:21])[CH3:20])=[C:17]([F:18])[C:12]3=[N:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].[S:23]1[CH:27]=[CH:26][C:25]2[CH:28]=[CH:29][CH:30]=[C:31](B(O)O)[C:24]1=2>>[S:23]1[CH:27]=[CH:26][C:25]2[CH:28]=[CH:29][CH:30]=[C:31]([C:2]3[CH:3]=[C:4]([C:9]4[N:13]5[CH:14]=[CH:15][C:16]([C:19]([OH:22])([CH3:21])[CH3:20])=[C:17]([F:18])[C:12]5=[N:11][CH:10]=4)[CH:5]=[CH:6][C:7]=3[F:8])[C:24]1=2

Participants

3

Reactant 2

HCID 166405281-Benzothien-7-ylboronic acidHCID 674866802-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-alpha]pyridin-7-yl]propan-2-ol

Product 1

HCID 10070752HCID 10070752, compoundYield 3%

Procedure

2-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-α]pyridin-7-yl]-propan-2-ol and benzo[b]thiophene-7-boronic acid were coupled in the same way as in Example 30 to give 2-{3-[3-(benzo[b]thien-7-yl)-4-fluorophenyl]-8-fluoroimidazo[1,2-α]pyridin-7-yl}propan-2-ol as an off-white solid (4 mg, 3%): m/z (ES+) 421 [MH+].

Sources & evidence

ORD record
ord-3fa65e9c6e7844128f0d9147c687dbd4
Source dataset
uspto-grants-2007_10
Patent number
US07279580B2

Reaction notes

Loading…