(3-Phenyl-1,2-oxazol-5-yl)boronic acid → HCID 11743464, compound

HRID 1180300Notes

Reaction equation

HRID 1180300 reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:9]2[N:13]3[CH:14]=[CH:15][C:16]([C:19]([OH:22])([CH3:21])[CH3:20])=[C:17]([F:18])[C:12]3=[N:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].[C:23]1([C:29]2[CH:33]=[C:32](B(O)O)[O:31][N:30]=2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[F:18][C:17]1[C:12]2[N:13]([C:9]([C:4]3[CH:5]=[CH:6][C:7]([F:8])=[C:2]([C:32]4[O:31][N:30]=[C:29]([C:23]5[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=5)[CH:33]=4)[CH:3]=3)=[CH:10][N:11]=2)[CH:14]=[CH:15][C:16]=1[C:19]([OH:22])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 4197358(3-Phenyl-1,2-oxazol-5-yl)boronic acidHCID 674866802-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-alpha]pyridin-7-yl]propan-2-ol

Product 1

HCID 11743464HCID 11743464, compoundYield 5%

Procedure

2-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-α]pyridin-7-yl]-propan-2-ol and 3-phenylisoxazole-5-boronic acid were coupled in the same way as in Example 30 to give 2-{8-fluoro-3-[4-fluoro-3-(3-phenylisoxazol-5-yl)phenyl]imidazo[1,2-α]pyridin-7-yl}propan-2-ol as an off-white solid (6 mg, 5%): m/z (ES+) 432 [MH+].

Sources & evidence

ORD record
ord-3195533fe69a4e0ea7e955ce4be3e474
Source dataset
uspto-grants-2007_10
Patent number
US07279580B2

Reaction notes

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