(2H-1,3-benzodioxol-5-yl)boronic acid → HCID 10092852, compound

HRID 1180310Notes

Reaction equation

HRID 1180310 reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:9]2[N:13]3[CH:14]=[CH:15][C:16]([C:19]([OH:22])([CH3:21])[CH3:20])=[C:17]([F:18])[C:12]3=[N:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].[O:23]1[C:27]2[CH:28]=[CH:29][C:30](B(O)O)=[CH:31][C:26]=2[O:25][CH2:24]1>>[O:23]1[C:27]2[CH:28]=[CH:29][C:30]([C:2]3[CH:3]=[C:4]([C:9]4[N:13]5[CH:14]=[CH:15][C:16]([C:19]([OH:22])([CH3:21])[CH3:20])=[C:17]([F:18])[C:12]5=[N:11][CH:10]=4)[CH:5]=[CH:6][C:7]=3[F:8])=[CH:31][C:26]=2[O:25][CH2:24]1

Participants

3

Reactant 2

HCID 2734371(2H-1,3-benzodioxol-5-yl)boronic acidHCID 674866802-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-alpha]pyridin-7-yl]propan-2-ol

Product 1

HCID 10092852HCID 10092852, compoundYield 4%

Procedure

2-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-α]pyridin-7-yl]-propan-2-ol and benzo[1,3]dioxole-5-boronic acid were coupled in the same way as in Example 30 to give 2-{3-[3-(benzo[1,3]dioxol-5-yl)-4-fluorophenyl]-8-fluoroimidazo[1,2-α]pyridin-7-yl}propan-2-ol as an off-white solid (8 mg, 4%): m/z (ES+) 409 [MH+].

Sources & evidence

ORD record
ord-53510c3f85ae46d39e4658d7f53e1b8b
Source dataset
uspto-grants-2007_10
Patent number
US07279580B2

Reaction notes

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