5'-Bromo-2',4-difluoro-[1,1'-biphenyl]-2-carbonitrile → 4,2'-Difluoro-5'-(8-fluoro-7-trifluoromethylimidazo[1,2-alpha]pyridin-3-yl)-biphenyl-2-carbonitrile

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Reaction Steps

8-Fluoro-7-trifluoromethylimidazo[1,2-α]pyridine (102 mg, 0.5 mmol) and 5′-bromo-4,2′-difluorobiphenyl-2-carbonitrile (221 mg, 0.75 mmol) were coupled following the procedure given in Example 6 to afford 4,2′-difluoro-5′-(8-fluoro-7-trifluoromethylimidazo[1,2-α]pyridin-3-yl)-biphenyl-2-carbonitrile (93 mg, 45%) as an off-white solid: δH (360 MHz, CDCl3) 7.00 (1H, dd, J 7 and 6), 7.40-7.47 (2H, m), 7.55 (1H, dd, J 8 and 3), 7.57-7.65 (3H, m), 7.86 (1H, s), 8.34 (1H, d, J 7); m/z (ES+) 418 (100%, [MH]+).

Provenance & Evidence