2-(5-Bromo-2-fluorophenyl)nicotinonitrile → 2-[2-Fluoro-5-(8-fluoro-7-trifluoromethylimidazo[1,2-alpha]pyridin-3-yl)phenyl]-nicotinonitrile

Participants

Reaction Steps

8-Fluoro-7-trifluoromethylimidazo[1,2-α]pyridine (102 mg, 0.5 mmol) and 2-(5-bromo-2-fluorophenyl)nicotinonitrile (208 mg, 0.75 mmol) were coupled following the procedure given in Example 6 to afford 2-[2-fluoro-5-(8-fluoro-7-trifluoromethylimidazo[1,2-α]pyridin-3-yl)phenyl]-nicotinonitrile (91 mg, 45%) as a white solid: δH (360 MHz, CDCl3) 6.98 (1H, dd, J 7 and 6), 7.44-7.54 (2H, m), 7.67-7.72 (1H, m), 7.79 (1H, dd, J 7 and 2), 7.88 (1H, s), 8.15 (1H, dd, J 7 and 2), 8.24 (1H, d, J 7), 8.95 (1H, d, J 2); m/z (ES+) 401 (100%, [MH]+).

Provenance & Evidence