HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triisopropyl borate → 3-Fluoro-4-methoxyphenylboronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triisopropyl borate | HCID 21531 | — |
| Reactant | 4-Bromo-2-fluoroanisole | HCID 75378 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 3-Fluoro-4-methoxyphenylboronic acid | HCID 2782194 | — |
Reaction Steps
The title compound was prepared by reacting 4-bromo-2-fluoroanisole (10 g, 0.049 moles) with n-butyl lithium (23.4 mL of 2.5 M solution in hexane, 0.059 moles) followed by triisopropyl borate (45.2 mL, 36.9 g, 0.196 moles) according to Method A to yield 7.1 g (85.2%) of a white solid: MS (ESI) m/z 169 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279600B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-bc4e86bc7a794eb5ae2ce36406c17597 |
| Source note | uspto-grants-2007_10 |