Hydroxyamine hydrochloride → HCID 136338602, compound

Participants

Reaction Steps

The title compound was prepared by reacting 3-chloro-3′-fluoro-4′-hydroxy-1,1′-biphenyl-4-carbaldehyde (1.52 mmol) with hydroxylamine hydrochloride (233 mg, 3.34 mmol) according to Method C to yield 260 mg (66%) of yellowish solid: mp 198-200° C.; 1H NMR (DMSO-d6): δ 7.03 (1H, t, J=8.79 Hz), 7.41-7.43 (1H, m), 7.60 (1H, dd, J=12.91 Hz, J=2.20 Hz), 7.64-7.66 (1H, m), 7.77 (1H, d, J=1.92 Hz), 7.84 (1H, d, J=8.24 Hz), 8.36 (1H, s),10.16 (1H, bs), 11.68 (1H, bs); MS (ESI) m/z 264/266 (M−H)−, 266/268 (M+H)+.

Provenance & Evidence