Hydroxyamine hydrochloride → HCID 136338605, compound

Participants

Reaction Steps

The title compound was prepared by reacting 3,5-dichloro-3′-fluoro-4′-hydroxy-1,1′-biphenyl-4-carbaldehyde (290 mg, mmol) with hydroxylamine hydrochloride (140 mg, 1.27 mmol) according to Method F to yield 260 mg (85%) of a white solid: mp 185-190° C.; 1H NMR (DMSO-d6): δ 7.03 (1H, t, J=8.86 Hz), 7.46-7.49 (1H, m), 7.68 (1H, dd, J=12.74 Hz, J=2.26 Hz), 7.82 (2H, s), 8.25 (1H, s), 10.24 (1H, s), 11.80 (1H, s); MS (ESI) m/z 298/300/302 (M−H)−, 300/302/304 (M+H)+.

Provenance & Evidence