反应详情

温度

85 °C

To a solution of N-(cyanomethyl)-4-methyl-2-{phenyl[4-(piperazin-1-ylcarbonyl)phenyl]methoxy}pentanamide from example 17, step 7 (79 mg, 0.18 mmol) in acetonitrile (1 mL), was added Na2CO3 (37 mg, 0.36 mmol) and 2-bromofluoroethane (39 μL, 0.525 mmol). The reaction was heated in a sealed tube at 85° C. for 16 hours and was then cooled down to room temperature. The mixture was then concentrated and the crude residue chromatographed on silica gel using 1% NH4OH and 9% methanol in dichloromethane to afford the title compound.

1. temperaturewas then cooled down to room temperature
2. concentrationThe mixture was then concentrated
3. customthe crude residue chromatographed on silica gel using 1% NH4OH and 9% methanol in dichloromethane