Methyl 2-bromo-4-methylpentanoate → HCID 69471669, compound

HRID 1180395Notes

Reaction equation

HRID 1180395 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[OH:9])=[CH:4][CH:3]=1.Br[CH:17]([CH2:22][CH:23]([CH3:25])[CH3:24])[C:18]([O:20][CH3:21])=[O:19]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[O:9][CH:17]([CH2:22][CH:23]([CH3:25])[CH3:24])[C:18]([O:20][CH3:21])=[O:19])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 12957039Methyl 2-bromo-4-methylpentanoateHCID 13282976(4-Bromophenyl)(pyridin-3-yl)methanol

Product 1

HCID 69471669HCID 69471669, compound

Procedure

Using the same protocol as described in example 23, step 2, (4-bromophenyl)(pyridin-3-yl)methanol from step 1 (644 mg, 2.4 mmol) was added to methyl 2-bromo-4-methylpentanoate (412 μL, 2.52 mmol). The crude residue was chromatographed on silica gel using 50% ethyl acetate in hexanes to afford the title compound.

Workup

  1. customThe crude residue was chromatographed on silica gel using 50% ethyl acetate in hexanes

Sources & evidence

ORD record
ord-ef4894ac603c45f79e5e5b6dd75584a2
Source dataset
uspto-grants-2007_10
Patent number
US07279478B2

Reaction notes

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