Potassium Hydroxide → HCID 69471331, compound

HRID 1180396Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)[O:9][CH:10]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:11]([O:13]C)=[O:12])=[CH:4][CH:3]=1.[OH-].[K+:26]>>[K+:26].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)[O:9][CH:10]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:11]([O-:13])=[O:12])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 69471669HCID 69471669, compound

Product 1

HCID 69471331HCID 69471331, compound

Procedure

Using the same protocol as described in example 17, step 5, methyl 2-[(4-bromophenyl)(pyridin-3-yl)methoxy]-4-methylpentanoate from step 2 (268 mg, 0.68 mmol) was hydrolysed with potassium hydroxide. The solid residue obtained was used as such in the next step.

Workup

customThe solid residue obtained

Sources & evidence

ORD record: ord-6bf838c12a134feead5d74a4e8092910
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07279478B2

Reaction notes

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