Potassium Hydroxide → 2-[(4-Bromophenyl)(pyridin-4-yl)methoxy]-4-methylpentanoic acid potassium salt

HRID 1180399Notes

Reaction equation

HRID 1180399 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=2)[O:9][CH:10]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:11]([O:13]C)=[O:12])=[CH:4][CH:3]=1.[OH-].[K+:26]>>[K+:26].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=2)[O:9][CH:10]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:11]([O-:13])=[O:12])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 69473358Methyl 2-[(4-bromophenyl)(pyridin-4-yl)methoxy]-4-methylpentanoate

Product 1

HCID 694721682-[(4-Bromophenyl)(pyridin-4-yl)methoxy]-4-methylpentanoic acid potassium salt

Procedure

Using the same protocol as described in example 17, step 5, methyl 2-[(4-bromophenyl)(pyridin-4-yl)methoxy]-4-methylpentanoate from step 2 (293 mg, 0.75 mmol) was hydrolysed with potassium hydroxide. The solid residue obtained was used as such in the next step.

Workup

  1. customThe solid residue obtained

Sources & evidence

ORD record
ord-b72668f28caa4aedb32fa74b63afb640
Source dataset
uspto-grants-2007_10
Patent number
US07279478B2

Reaction notes

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