反应详情

Typically, the deprotection step comprises heating to reflux trityl candesartan cilexetil in methanol. Optionally, the deprotection solvent mixture further comprises an organic solvent, such as toluene, and/or an acid, such as formic acid. The cilexetil trityl candesartan is heated to reflux until a clear solution is obtained. Typically, the reaction temperature is from about 30° C. to about 90° C., preferably from about 50° C. to about 90° C., and the heating takes place for about 5 to about 19 hours, preferably for about 8 to about 12 hours. Thereafter, the solvents are removed by evaporation to obtain crude deprotected candesartan cilexetil. The solvents may be removed at a temperature of about 30° C. to about 70° C., preferably at a temperature of about 50° C., and at a reduce pressure of about 30 mbar.

1. temperatureTypically, the deprotection step comprises heating
2. temperatureto reflux until a clear solution
3. customis obtained
4. customis from about 30° C. to about 90° C., preferably from about 50° C. to about 90° C.
5. customfor about 5 to about 19 hours
6. waitpreferably for about 8 to about 12 hours
7. customThereafter, the solvents are removed by evaporation