反应详情

Using the same protocol as described in example 21, 2-[(4-bromophenyl)(1,3-thiazol-2-yl)methoxy]-N-(cyanomethyl)-4-methylpentanamide from example 27, step 4 (225 mg, 0.53 mmol) was coupled with 4-piperazin-1-ylphenylboronic acid (141 mg, 0.58 mmol). The crude residue obtained was chromatographed on silica gel using 1% NH4OH and 9% MeOH in dichloromethane to afford the title compound.

1. customThe crude residue obtained
2. customwas chromatographed on silica gel using 1% NH4OH and 9% MeOH in dichloromethane