反应详情

Sodium Hydride (60%, 0.87 mmol) was suspended in Et2O (9 mL) and a solution of 1-(4-bromophenyl)-2-methylpropan-1-ol of step 1 (8.7 mmol, 2.0 g) in Et2O (6 mL) was added. The mixture was stirred at r.t. for 0.25 h. The mixture was cooled to 0° C. Trichloroacetonitrile (11 mmol) was added. The mixture was allowed to warmed to r.t. over 1 h. The mixture was diluted with EtOAc and washed with NaHCO3. The organic extract was dried (anhyd. MgSO4) and concentrated under reduced pressure to give an oil. Chromatography (10% Acetone/EtOAc) gave the title compound.

1. temperatureThe mixture was cooled to 0° C
2. temperatureto warmed to r.t. over 1 h
3. washwashed with NaHCO3
4. extractionThe organic extract
5. dry with materialwas dried (anhyd. MgSO4)
6. concentrationconcentrated under reduced pressure
7. customto give an oil