2-Bromoethyl methyl ether → HCID 69472218, compound

Participants

Reaction Steps

A solution of methyl (2S)-4-methyl-2-{[(R)-phenyl(4-pyridin-3-ylphenyl)methyl]oxy}pentanoate from example 36 step 2 (740 mg, 1.9 mmol) and 2-bromoethyl methyl ether (1.32 g, 9.5 mmol) in acetonitrile (10 mL) was heated in a pressure tube emersed in an oil bath at 120+ C. for 18 hours. The mixture was concentrated and the residue slurried with diethyl ether (25 mL) 2 times followed by decanting and then pumped on by high vacuum to obtain the title compound as a foam.

Provenance & Evidence