Quinoline-3-boronic acid → methyl (2S)-4-methyl-2-{[(R)-phenyl(4-quinolin-3-ylphenyl)methyl]oxy}pentanoate

Participants

Reaction Steps

Using the same procedure as described for example 36 step 2, methyl (2S)-2-{[(R)-(4-bromophenyl)(phenyl)methyl]oxy}-4-methylpentanoate (2.05 g, 5.25 mmol) and 3-quinolineboronic acid (1.0 g, 5.78 mmol) were coupled to give the title compound as an oil.

Provenance & Evidence