Diazomethane → Methyl 2-bromo-4-methylpentanoate

HRID 1180447Notes

Reaction equation

HRID 1180447 reaction equation
[Br:1][CH:2]([CH2:6][CH:7]([CH3:9])[CH3:8])[C:3]([OH:5])=[O:4].[N+](=[CH2:12])=[N-]>C(Cl)Cl>[Br:1][CH:2]([CH2:6][CH:7]([CH3:9])[CH3:8])[C:3]([O:5][CH3:12])=[O:4]

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 1426812-Bromo-4-methylpentanoic acid

Product 1

HCID 12957039Methyl 2-bromo-4-methylpentanoate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-bromo-4-methylpentanoic acid (9.86 mmol, 1.31 g) in CH2Cl2 (100 mL), was added slowly a solution of diazomethane until no bubbles appears. The mixture was stirred at r.t. for 0.25 h. The volatiles were removed under reduced pressure to leave a yellow liquid. The crude methyl ester was used without further purification.

Workup

  1. customThe volatiles were removed under reduced pressure
  2. customto leave a yellow liquid
  3. customThe crude methyl ester was used without further purification

Sources & evidence

ORD record
ord-4beed7d2eade45598f589e1e5814a025
Source dataset
uspto-grants-2007_10
Patent number
US07279478B2

Reaction notes

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