Hydrochloric Acid → 1-(4-Bromophenyl)-2,2,2-trifluoroethanol

Participants

Reaction Steps

To a solution of 1-(4-bromophenyl)-2,2,2-trifluoroethanone (37.7 mmol, 8.86 g) in methanol (89 mL) at 0° C., was added sodium borohydride (39.6, 1.50 g). The mixture was stirred for 1 h. HCl 10% (100 mL) was added and the mixture was stirred for 0.25 h. The mixture was extracted with CH2Cl2. The combined extracts were dried over anhydrous MgSO4 and concentrated under reduced pressure. The crude alcohol was used without further purification.

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