Hydrochloric Acid → HCID 69472731, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of methyl 4methyl-2-(2,2,2-trifluoro-1-phenylethoxy)pentanoate from example 69 step 3 (0.63 mmol, 241 mg) in pyridine (7 mL), lithium iodide (1.26 mmol, 168 mg) was added and the mixture was heated at 140° C. for 24 h. The mixture was cooled to r.t. HCl 10% (20 mL) was added and HCl 12 N was added until pH 1. The mixture was extracted with ethyl acetate (50 mL) 3×. The combined extracts were dried over anhydrous MgSO4 and concentrated. The crude title acid was used without further purification.

Provenance & Evidence