HCID 178481189, compound → HCID 178481188, compound

HRID 1180466Notes

Reaction equation

HRID 1180466 reaction equation
[CH3:1][N:2]1[C@@H:6]2[CH2:7][C@@H:8]([O:10][C:11]([C@@H:13]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:14][OH:15])=[O:12])[CH2:9][C@H:3]1[CH2:4][CH2:5]2.OS(O)(=O)=O>O>[CH3:1][N:2]1[C@@H:6]2[CH2:7][C@@H:8]([O:10][C:11]([C@@H:13]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:14][OH:15])=[O:12])[CH2:9][C@H:3]1[CH2:4][CH2:5]2

Participants

3

Reactant 1

HCID 178481189HCID 178481189, compound

Product 1

HCID 178481188HCID 178481188, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Hyoscyamine sulfate (0.188 kg) is added to 2.0 kg of Purified Water, USP, in a stainless steel container. An additional 1.0 kg of Purified Water, USP, is added to rinse the remaining hyoscyamine suflate, and the rinse solution is added to the solution in the stainless steel container to form a concentrated hyoscyamine solution. The concentrated hyoscyamine solution is transferred, with slow addition, to a stainless steel mixing tank containing 15.0 kg of Purified Water, USP. The stainless steel mixing tank is equipped with a mixer, and the resulting diluted hyoscyamine solution is mixed slowly for 15 minutes. The container used to prepare the concentrated hyoscyamine solution is rinsed with an additional 1.0 kg of Purified Water, USP, and the rinse solution is added to the stainless steel mixing tank containing the mixed diluted hyoscyamine solution.

Workup

  1. washto rinse the remaining hyoscyamine suflate
  2. additionthe rinse solution is added to the solution in the stainless steel container

Sources & evidence

ORD record
ord-d7c01a4c67d9453fa4fc36148ce5065d
Source dataset
uspto-grants-2007_10
Patent number
US07282217B1

Reaction notes

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