Formic Acid → HCID 22053518, compound

HRID 1180500Notes

Reaction equation

HRID 1180500 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH2:13][CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:2]=1.[CH:14](O)=O.C=O>O>[CH3:14][N:10]1[CH2:11][CH2:12][CH2:13][N:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH2:8][CH2:9]1

Participants

5

Reactant 3

HCID 284Formic AcidHCID 712FormaldehydeHCID 106548911-pyridin-3-yl-1,4-diazepane

Product 1

HCID 22053518HCID 22053518, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 1-(3-pyridyl)-homopiperazine (0.42 g, 2.4 mmol), formic acid (3.3 g, 71.7 mmol), formaldehyde (2.1 g, 37%) and water (10 ml) was stirred at reflux for 15 hours. The mixture was evaporated and sodium hydroxide (15 ml, 4 M) was added and the product was extracted two times with ethyl acetate (15 ml). The product was obtained as an oil. Yield 0.46 g, 100%.

Workup

  1. temperatureat reflux for 15 hours
  2. customThe mixture was evaporated
  3. additionsodium hydroxide (15 ml, 4 M) was added
  4. extractionthe product was extracted two times with ethyl acetate (15 ml)
  5. customThe product was obtained as an oil

Sources & evidence

ORD record
ord-d7d75d6fd51e4da1acc9b5948e078efa
Source dataset
uspto-grants-2007_10
Patent number
US07282494B2

Reaction notes

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