1,3-Dichloro-5,5-dimethylhydantoin → HCID 22053547, compound

HRID 1180504Notes

Reaction equation

HRID 1180504 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]2)[CH:5]=[N:6][CH:7]=1.[Cl:22]N1C(C)(C)C(=O)N(Cl)C1=O>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]2)[CH:5]=[N:6][C:7]=1[Cl:22]

Participants

4

Reactant 2

HCID 83601,3-Dichloro-5,5-dimethylhydantoinHCID 11507869HCID 11507869, compound

Product 1

HCID 22053547HCID 22053547, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 1-(5-chloro-3-pyridyl)-4-tert-butoxycarbonylhomopiperazine (1.56, 5.0 mmol), 1,3-dichloro-5,5-dimethylhydantoin (0.985 g, 5.0 mmol) and dichloromethane (50 ml) was stirred for 180 minutes. The crude mixture was evaporated and purified by chromatography on silica gel using ethyl acetate:petroleum (3:1) as solvent. Yield 0.46 g, 27%.

Workup

  1. customThe crude mixture was evaporated
  2. custompurified by chromatography on silica gel

Sources & evidence

ORD record
ord-9f29675c18b6431a9681844ef170fd37
Source dataset
uspto-grants-2007_10
Patent number
US07282494B2

Reaction notes

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