Bromosuccinimide → HCID 22053520, compound

HRID 1180509Notes

Reaction equation

HRID 1180509 reaction equation
[Br:1]C1CC(=O)NC1=O.[CH3:9][O:10][C:11]1[CH:12]=[C:13]([N:17]2[CH2:23][CH2:22][CH2:21][N:20]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:19][CH2:18]2)[CH:14]=[N:15][CH:16]=1>C(#N)C>[Br:1][C:16]1[N:15]=[CH:14][C:13]([N:17]2[CH2:23][CH2:22][CH2:21][N:20]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:19][CH2:18]2)=[CH:12][C:11]=1[O:10][CH3:9]

Participants

4

Reactant 2

HCID 38309BromosuccinimideHCID 22478599HCID 22478599, compound

Product 1

HCID 22053520HCID 22053520, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Bromosuccinimide (3.56 g, 20.0 mmol) was added to a mixture of 1-(5-methoxy-3-pyridyl)-4-tert-butoxycarbonyl homopiperazine (6.14 g, 20.0 mmol) and acetonitrile (200 ml) at room-temperature and stirred for 20 minutes. The mixture was evaporated and purified by chromatography on silica gel with ethyl acetate and petroleum (1:1) as solvent and gave 4.4 g, 57% of the title compound.

Workup

  1. customThe mixture was evaporated
  2. custompurified by chromatography on silica gel with ethyl acetate and petroleum (1:1) as solvent

Sources & evidence

ORD record
ord-aaebdfedf1e74e409332c90eff987b3b
Source dataset
uspto-grants-2007_10
Patent number
US07282494B2

Reaction notes

Loading…