Hydrochloric Acid → HCID 131726642, compound

Participants

Reaction Steps

1-(6-Amino-3-pyridyl)-homopiperazine (96 mg, 0.5 mmol) was solyed in conc. hydrochloric acid (2.0 ml). Sodium nitrite (45 mg, 0.65 mmol) was added at 0° C. The mixture was allowed to reach room-temperature and was stirred overnight. The mixture was poured out on water (20 ml) and was refluxed for 10 minutes. The mixture was made alkaline by adding aqueous sodium hydroxide (1.0 ml, 4 M). The mixture was extracted with ethyl acetate (3×10 ml). The product was isolated as an oil. Yield 50 mg (47%). The free base was converted to the corresponding fumaric acid salt. Mp. 165-167° C.

Provenance & Evidence