HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-{[4-(2,3-Butadienyloxy)phenyl]sulfonyl}valine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 2-[{[4-(2,3-butadienyloxy)phenyl]sulfonyl}(methyl)amino]-3-methylbutanoate | HCID 85826253 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-{[4-(2,3-Butadienyloxy)phenyl]sulfonyl}valine | HCID 86588656 | 89.3% |
Reaction Steps
The procedure of Example 12 was followed using the product from Example 14 (300 mg, 0.85 mmol) and lithium hydroxide (41 mg, 1.7 mmol) in tetrahydrofuran (3 ml), methanol (3 ml), and water (1.5 ml) to give 247 mg (86%) of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07282496B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-435ccad00add432985b7c0b7596e1216 |
| Source note | uspto-grants-2007_10 |