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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1180551Generated: November 3, 2026

Water → [(4-(2,3-Butadienyloxy)phenyl]sulfonyl}-2,2-dimethyl-3-thiomorpholinecarboxylic acid

https://huagongshe.com/reaction/1180551

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantLithium HydroxideHCID 3939—
ReactantMethyl (3S)-4-{[4-(2,3-butadienyloxy)phenyl]sulfonyl}-2,2-dimethyl-3-thiomorpholinecarboxylateHCID 86588660—
SolventMethanolHCID 887—
SolventTetrahydrofuranHCID 8028—
Product[(4-(2,3-Butadienyloxy)phenyl]sulfonyl}-2,2-dimethyl-3-thiomorpholinecarboxylic acidHCID 5897893053%

Reaction Steps

The procedure of Example 12 was followed using the product from Example 24 (150 mg, 0.38 mmol), lithium hydroxide (18 mg, 0.76 mmol) in tetrahydrofuran (2 ml), methanol (2 ml), and water (1 ml) to give 50 mg of product (53%, based on unreacted starting material).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07282496B2
Source datasetuspto-grants-2007_10
ORD IDord-39d0c6fd9bd64b20bdd69ed208dca512
Source noteuspto-grants-2007_10