反应详情

8-Bromo-[1,6]naphthyridine-2-carboxylic acid methyl ester (2) is prepared by combining compound 1 (1 equiv.), cesium carbonate (1.1 equiv.) and methyl iodide (1.1 equiv.) in DMF (10 mL) and stirring for 16 hrs. at room temperature. The reaction is concentrated in vacuo to give a brown solid, which is dissolved in EtOAc (50 mL) and washed with water (2×50 mL). The EtOAc layer is dried over sodium sulfate, filtered, and concentrated in vacuo to afford a purple solid. The crude product is purified via silica gel chromatography (EtOAc) to yield (2) as a yellow solid, 65%, LC/MS (M+H) 269.0.

1. custom8-Bromo-[1,6]naphthyridine-2-carboxylic acid methyl ester (2) is prepared
2. customat room temperature
3. concentrationThe reaction is concentrated in vacuo
4. customto give a brown solid, which
5. washwashed with water (2×50 mL)
6. dry with materialThe EtOAc layer is dried over sodium sulfate
7. filtrationfiltered
8. concentrationconcentrated in vacuo
9. customto afford a purple solid
10. customThe crude product is purified via silica gel chromatography (EtOAc)