反应详情

Compound 3 (above, 1 equiv.), 5-(dihydroxylboryl)-2-thiophene carboxylic acid (1 equiv.), dichloro(bistriphenylphosphine)palladium (II) (0.02 equiv.), and sodium carbonate (1.5 equiv.) are combined with 7:3:2; DME:water:methanol (4 mL) in a microwavable reaction tube. The reaction mixture is irradiated in the microwave at 140° C. for 300 seconds and then cooled to room temperature. The crude mixture is concentrated in vacuo, affording a green-brown solid. Purification via silica gel chromatography (EtOAc to 4:1; EtOAc:methanol containing 1% acetic acid) affords a bright yellow solid. LC/MS (M+H) 340.2.

1. customThe reaction mixture is irradiated in the microwave at 140° C. for 300 seconds
2. concentrationThe crude mixture is concentrated in vacuo
3. customaffording a green-brown solid
4. customPurification via silica gel chromatography (EtOAc to 4:1; EtOAc:methanol containing 1% acetic acid)
5. customaffords a bright yellow solid