1-Ethylsulfanyl-2-methyl-but-3-yn-2-ol → 1-Ethylsulfanyl-2-(5-fluoro-1-methanesulfonyl-6-trifluoromethyl-1H-indol-2-yl)-propan-2-ol

HRID 1180591Notes

Reaction equation

HRID 1180591 reaction equation
[F:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[C:4](I)[CH:3]=1.[CH2:18]([S:20][CH2:21][C:22]([CH3:26])([OH:25])[C:23]#[CH:24])[CH3:19]>>[CH2:18]([S:20][CH2:21][C:22]([C:23]1[N:12]([S:13]([CH3:16])(=[O:15])=[O:14])[C:5]2[C:4]([CH:24]=1)=[CH:3][C:2]([F:1])=[C:7]([C:8]([F:11])([F:10])[F:9])[CH:6]=2)([OH:25])[CH3:26])[CH3:19]

Participants

3

Reactant 2

HCID 589795961-Ethylsulfanyl-2-methyl-but-3-yn-2-olHCID 58979618N-(4-fluoro-2-iodo-5-trifluoromethyl-phenyl)-methanesulfonamide

Product 1

HCID 116110141-Ethylsulfanyl-2-(5-fluoro-1-methanesulfonyl-6-trifluoromethyl-1H-indol-2-yl)-propan-2-ol

Procedure

This compound was prepared using the general Sonagashira procedure as described in the General Procedures Example C. The starting material was N-(4-fluoro-2-iodo-5-trifluoromethyl-phenyl)-methanesulfonamide (0.77 g, 2.0 mmol) and 1-ethylsulfanyl-2-methyl-but-3-yn-2-ol (0.29 g, 2.0 mmol), reacted to yield the title compound as a golden oil.

Workup

  1. customThis compound was prepared
  2. customreacted

Sources & evidence

ORD record
ord-9a1596f35ea94a97bc4fcca52bb981e1
Source dataset
uspto-grants-2007_10
Patent number
US07282507B2

Reaction notes

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