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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1180596Generated: October 29, 2026

Sodium Hydroxide → 2-Ethylsulfanyl-1-(5-nitro6-trifluoromethyl-1H-indol-2-yl)-ethanol

https://huagongshe.com/reaction/1180596

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
Reactant2-ethylsulfanyl-1-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl)-ethanolHCID 11502477—
Product2-Ethylsulfanyl-1-(5-nitro6-trifluoromethyl-1H-indol-2-yl)-ethanolHCID 11681533—

Reaction Steps

This compound was prepared using the general de-protection procedure described in General Procedures Example B, starting from 2-ethylsulfanyl-1-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl)-ethanol (1.52 g, 3.69 mmol) and 4M sodium hydroxide as base (1.8 mL, 7.38 mmol) to yield the title compound as a bright yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07282507B2
Source datasetuspto-grants-2007_10
ORD IDord-d31cc9ade38f4fea8f3e5cb081b53905
Source noteuspto-grants-2007_10