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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1180615Generated: November 4, 2026

Amantadine → Benzamide

https://huagongshe.com/reaction/1180615

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmantadineHCID 2130—
ReactantAnilineHCID 6115—
ReactantEthyl chloroformateHCID 10928—
Reactant1,4-Benzenedicarboxylic acid, methyl esterHCID 3614454—
ProductBenzamideHCID 2331—

Reaction Steps

As shown in the reaction scheme 2, firstly, monomethylterephthalate may be converted to an anhydride by employing ethyl chloroformate. Then, the anhydride may be reacted with aniline or adamantamine, to produce a benzamide compound. The next reactions may be performed by the same procedure described in the reaction scheme 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07282522B2
Source datasetuspto-grants-2007_10
ORD IDord-bea8b36ed47e404f8554f44a01ed6be7
Source noteuspto-grants-2007_10