HCID 23571150, compound → HCID 23571151, compound

Participants

Reaction Steps

A mixture of the tetrahydropyridine from Example 41 (0.018 g, 0.029 mmol), palladium on carbon (0.01 g) and ethyl acetate (2 mL) was stirred under 1 atmosphere of hydrogen for 16 hours. The catalyst was removed by filtration through a glass fibre pad and the solvent removed in vacuo to give the title compound (0.018 g, quant.). δ (1H, 400 MHz, CDCl3) 1.29-1.38 (2H, m), 1.68-1.82 (4H, m), 2.16-2.20 (2H, m), 2.46-2.49 (2H, m), 2.70-2.80 (2H, m), 2.92-2.98 (1H, m), 3.18-3.33 (4H, m), 3.44 (2H, s), 3.64-3.72 (2H, m), 4.11-4.15 (1H, m), 4.64 (1H, d, J=14 Hz), 4.91 (1H, s) 7.15 (1H, d, J=7.8 Hz), 7.55 (1H, d, J=0.7 Hz), 7.61 (1H, dd, J=1.5 & 7.8 Hz), 7.66 (1H, s). MS (ES+) 623 ([MH]+).

Provenance & Evidence