2,4-Difluorophenylboronic acid → CID 23571062

Participants

Role	Name	HCID	Charge
Reactant	2,4-Difluorophenylboronic acid	HCID 2734334	—
Reactant	[6s,9r,11r]2',3',4',5,5',6,7,8,9,10-Decahydro-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-5'-(2,2,2-trifluoroethyl)spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazole]1',1'-dioxide	HCID 23571079	—
Reactant	HCID 178418934	HCID 178418934	—
Product	CID 23571062	HCID 23571062	—

Reaction Steps

Prepared from 4-bromo-1H-imidazole, 2,4-difluorophenylboronic acid and homochiral boronate from Example 24 Step 1 following the procedures in Example 76 Steps 1 and 2. δ (1H, 360 MHz, CDCl3) 1.20-1.27 (2H, m), 1.69-1.73 (2H, m), 2.45-2.47 (2H, m), 2.68-2.82 (2H, m), 3.20-3.26 (2H, m), 3.43 (2H, s), 3.68 (2H, q, J=8.7 Hz), 4.71 (1H, s), 7.00-7.13 (3H, m), 7.40-7.45 (2H, m), 7.54 (1H, d, J=7.9 Hz), 7.61 (1H, s), 7.78 (1H, s). MS (ES+) 539 ([MH]+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07282513B2
Source dataset	uspto-grants-2007_10
ORD ID	ord-af37e7924cb84626ace001f3ecc1675b
Source note	uspto-grants-2007_10