Glycine → HCID 56619281, compound

Participants

Reaction Steps

DCC (308 mg, 1.5 mmol) was added to a DMF solution (10 mL) of HABA-Gly-OH (299 mg, 1 mmol) and PfpOH (276 mg, 1.5 mmol) while ice cooling, and the reaction mixture was stirred at room temperature for 15 hours. The reaction mixture was filtered, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (0-5% acetone/CH2Cl2) to give HABA-Gly-OPfp (46 mg, 10%) as an orange powder. 1H NMR (CDCl3) δ 9.67 (brs, 1H), 9.02 (brt, 1H), 7.8-7.7 (m, 3H), 7.6-7.5 (m, 2H), 7.23 (d, J=9 Hz, 1H), 6.86 (d, J=9 Hz, 2H), 4.67 (d, J=5 Hz, 2H).

Provenance & Evidence