Methanol → HCID 44391097, compound

Participants

Reaction Steps

To a solution of benzofuran-6-sulfonamide (120 mg, 0.608 mmol) in CH2Cl2 (3.6 mL) and pyridine (2.3 mL) is added DMAP (75 mg, 0.611 mmol) and 2,4-dichlorobenzoyl chloride (153 mg, 0.730 mmol) and the reaction is stirred at room temperature overnight. The reaction mixture is diluted with CH2Cl2 then washed with 2 M HCl (2×) and dried (MgSO4). The organic solution is filtered and evaporated under vacuum to give the crude product. Flash chromatography on silica gel eluting with a gradient {CH2Cl2to CH2Cl2:(CHCl3:MeOH) [4:1(9:1)]} gives the title compound as a tan solid. ES(−)MS m/z 368, (M−H)− consistent with 2 Cl.

Provenance & Evidence