反应详情

A mixture of trityl candesartan cilexetil (20 g, 23.45 mmol), methanol (200 ml), and water (1 ml) was gently refluxed for about 16–17 h. The reaction progress was monitored by HPLC. The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of 55° C. to 60° C. to obtain viscous oil of candesartan cilexetil as a residue.

1. temperaturewas gently refluxed for about 16–17 h
2. customThe solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of 55° C. to 60° C.