反应详情

A solution of 0.218 g (0.5 mmol) of N-phenyloxycarbonyl-N-(2-allyloctanoyl)-1-(R)-phenylethylamine in 2 ml of methanol was cooled to 0° C., 0.38 g (1.0 mmol) of LiOMe was added, and the mixture was stirred for 22 hours. The reaction was terminated by addition of 2 ml of 1 N hydrochloric acid, and the product was extracted with ethyl acetate (30 ml×2). The extract was dried over anhydrous sodium sulfate, and the solvent was distilled off. The residue was quantitated by GC. Thus was obtained 0.057 g (58%) of the title compound.

1. customThe reaction was terminated by addition of 2 ml of 1 N hydrochloric acid
2. extractionthe product was extracted with ethyl acetate (30 ml×2)
3. dry with materialThe extract was dried over anhydrous sodium sulfate
4. distillationthe solvent was distilled off