4-Chlorothieno[3,2-d]pyrimidine → HCID 11736812, compound

HRID 1180781Notes

Reaction equation

HRID 1180781 reaction equation
[OH:1][CH2:2][C:3]1([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4]1.Cl[C:10]1[C:11]2[S:18][CH:17]=[CH:16][C:12]=2[N:13]=[CH:14][N:15]=1>>[N:13]1[C:12]2[CH:16]=[CH:17][S:18][C:11]=2[C:10]([O:1][CH2:2][C:3]2([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4]2)=[N:15][CH:14]=1

Participants

3

Reactant 2

HCID 27358214-Chlorothieno[3,2-d]pyrimidineHCID 4498243Cyclobutane-1,1-diyldimethanol

Product 1

HCID 11736812HCID 11736812, compound

Procedure

The title compound was prepared using the same experimental procedure as in example 25a using [1-(hydroxymethyl)cyclobutyl]methanol and 4-chlorothieno[3,2-d]pyrimidine. 1H NMR (300 MHz, CDCl3) δ 8.70 (s, 1H), 7.87 (d, J=5 Hz, 1H), 7.49 (d, J=5 Hz, 1H), 4.69 (s, 2H), 3.61 (d, J=6 Hz, 2H), 3.36 (t, J=6 Hz, 1H), 2.01-1.82 (m, 6H). GC-MS m/z 251 (M+H).

Sources & evidence

ORD record
ord-9762c0a432154bc0bac12068e4fd18eb
Source dataset
uspto-grants-2007_10
Patent number
US07282512B2

Reaction notes

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