2-Chloropyrimidine → {1-[(2-Pyrimidinyloxy)methyl]cyclobutyl}methanol

HRID 1180782Notes

Reaction equation

HRID 1180782 reaction equation
[OH:1][CH2:2][C:3]1([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4]1.Cl[C:10]1[N:15]=[CH:14][CH:13]=[CH:12][N:11]=1>>[N:11]1[CH:12]=[CH:13][CH:14]=[N:15][C:10]=1[O:1][CH2:2][C:3]1([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 744042-ChloropyrimidineHCID 4498243Cyclobutane-1,1-diyldimethanol

Product 1

HCID 11401306{1-[(2-Pyrimidinyloxy)methyl]cyclobutyl}methanol

Procedure

The title compound was prepared using the same experimental procedure as in example 25a from [1-(hydroxymethyl)cyclobutyl]methanol and 2-chloropyrimidine. 1H NMR (300 MHz, CDCl3) δ 8.50-8.47 (m, 2H), 6.95-6.89 (m, 1H), 4.48 (s, 2H), 3.63 (d, J=6 Hz, 2H), 3.02 (t, J=6 Hz, 1H), 2.01-1.78 (m, 6H). GC-MS m/z 195 (M+H).

Sources & evidence

ORD record
ord-e8e7112c1f9749dba2b5827bf0d1b0ab
Source dataset
uspto-grants-2007_10
Patent number
US07282512B2

Reaction notes

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