HCID 68998425, compound → HCID 68995166, compound

HRID 1180925Notes

Reaction equation

HRID 1180925 reaction equation
Br[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[N:8]([S:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)(=[O:22])=[O:21])[C:9]([C:11]3[CH:12]=[C:13]([N:17]([CH3:19])[CH3:18])[CH:14]=[CH:15][CH:16]=3)=[CH:10][C:3]=12.Br[C:30]1[C:31]([C:37]2[CH:42]=[CH:41][C:40]([NH:43][C:44](=[O:48])[N:45]([CH3:47])[CH3:46])=[CH:39][CH:38]=2)=[N:32][N:33]([CH2:35][CH3:36])[CH:34]=1>>[CH3:18][N:17]([CH3:19])[C:13]1[CH:12]=[C:11]([C:9]2[N:8]([S:20]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)(=[O:21])=[O:22])[C:4]3=[N:5][CH:6]=[CH:7][C:2]([C:30]4[C:31]([C:37]5[CH:42]=[CH:41][C:40]([NH:43][C:44](=[O:48])[N:45]([CH3:47])[CH3:46])=[CH:39][CH:38]=5)=[N:32][N:33]([CH2:35][CH3:36])[CH:34]=4)=[C:3]3[CH:10]=2)[CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 68998425HCID 68998425, compoundHCID 68999367N'-[4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)phenyl]-N,N-dimethylurea

Product 1

HCID 68995166HCID 68995166, compound

Procedure

Following the procedure described for Intermediate 32 with {3-[4-bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]phenyl}dimethylamine. Using this product crude and following the procedure described in Intermediate 100 using N′-[4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)phenyl]-N,N-dimethylurea provided the title product. ESMS [M+H]+: 634.6

Sources & evidence

ORD record
ord-cdc012e789ef45cf8eacbb924ff23ac6
Source dataset
uspto-grants-2007_10
Patent number
US07282588B2

Reaction notes

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