1-{4-[1-(Benzenesulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl]phenyl}-N,N-dimethylmethanamine → HCID 68999655, compound

HRID 1180931Notes

Reaction equation

HRID 1180931 reaction equation
[CH3:1][N:2]([CH3:37])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:27](S(C3C=CC=CC=3)(=O)=O)[C:13]3=[N:14][CH:15]=[CH:16][C:17](B4OC(C)(C)C(C)(C)O4)=[C:12]3[CH:11]=2)=[CH:6][CH:5]=1.Br[C:39]1[C:40]([C:45]2[CH:50]=[CH:49][C:48]([N+:51]([O-:53])=[O:52])=[CH:47][CH:46]=2)=[N:41][N:42]([CH3:44])[CH:43]=1>>[CH3:1][N:2]([CH3:37])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:27][C:13]3=[N:14][CH:15]=[CH:16][C:17]([C:39]4[C:40]([C:45]5[CH:50]=[CH:49][C:48]([N+:51]([O-:53])=[O:52])=[CH:47][CH:46]=5)=[N:41][N:42]([CH3:44])[CH:43]=4)=[C:12]3[CH:11]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 497590791-{4-[1-(Benzenesulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl]phenyl}-N,N-dimethylmethanamineHCID 690016754-bromo-1-methyl-3-(4-nitrophenyl)-1H-pyrazole

Product 1

HCID 68999655HCID 68999655, compound

Procedure

Following the procedure described in Intermediate 100 and Intermediate 21 using N,N-dimethyl-1-{4-[1-(phenylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl]phenyl}methanamine and 4-bromo-1-methyl-3-(4-nitrophenyl)-1H-pyrazole provided the title compound. ESMS [M+H]+: 453.2.

Sources & evidence

ORD record
ord-6aff75dfbffe4c7abe1d4cd07dab3216
Source dataset
uspto-grants-2007_10
Patent number
US07282588B2

Reaction notes

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