N'-[4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)phenyl]-N,N-dimethylurea → HCID 68998546, compound

HRID 1180943Notes

Reaction equation

HRID 1180943 reaction equation
[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([C:14]3[N:23]([S:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)(=[O:26])=[O:25])[C:17]4=[N:18][CH:19]=[CH:20][C:21](Br)=[C:16]4[CH:15]=3)=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2].Br[C:34]1[C:35]([C:41]2[CH:46]=[CH:45][C:44]([NH:47][C:48](=[O:52])[N:49]([CH3:51])[CH3:50])=[CH:43][CH:42]=2)=[N:36][N:37]([CH2:39][CH3:40])[CH:38]=1>>[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([C:14]3[N:23]([S:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)(=[O:26])=[O:25])[C:17]4=[N:18][CH:19]=[CH:20][C:21]([C:34]5[C:35]([C:41]6[CH:46]=[CH:45][C:44]([NH:47][C:48](=[O:52])[N:49]([CH3:51])[CH3:50])=[CH:43][CH:42]=6)=[N:36][N:37]([CH2:39][CH3:40])[CH:38]=5)=[C:16]4[CH:15]=3)=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 68999367N'-[4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)phenyl]-N,N-dimethylureaHCID 69003931HCID 69003931, compound

Product 1

HCID 68998546HCID 68998546, compound

Procedure

Following the procedure described for Intermediate 32 with 2-acetyl-7-[4-bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,2,3,4-tetrahydroisoquinoline. Using this product crude and following the procedure described in Intermediate 100 using N′-[4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)phenyl]-N,N-dimethylurea and stirring for 4.5 hours provided the title compound. ESMS [M+H]+: 688.6.

Sources & evidence

ORD record
ord-4d23f687284f48f69704ce2dd89d66f5
Source dataset
uspto-grants-2007_10
Patent number
US07282588B2

Reaction notes

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