反应详情

A solution of 4-bromo-2-iodo-1-(phenylsulfonyl)-2-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridine (0.44 mmol), 3-pyridinyl boronic acid (0.35 mmol) and tetrakis(triphenylphosphine) palladium(0) (0.013 mmol) in a 4:1 solution of 1,4-dioxane (4 mL):saturated sodium carbonate (1 mL) was stirred for 18 h at 100° C. in a sealed tube. After concentrated in vacuo, the residue was partitioned between ethyl acetate (5 mL) and water (5 mL). The organic layer was washed with brine (1×5 mL), dried over magnesium sulfate, and concentrated. Purification by flash chromatography (0-20% ethyl acetate/dichloromethane) provided the title compound as a yellow oil (50%). ESMS [M+H]+: 414.8.

1. concentrationAfter concentrated in vacuo
2. customthe residue was partitioned between ethyl acetate (5 mL) and water (5 mL)
3. washThe organic layer was washed with brine (1×5 mL)
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated
6. customPurification by flash chromatography (0-20% ethyl acetate/dichloromethane)