Sulfuric Acid → HCID 10999783, compound

Temperature

90 °C

In a 100 mL flask, 4-oxo-3-(3-phenyl-propionylamino)-pentanoic acid methyl ester (10 g, 36 mmol) and acetic anhydride (28 mL) were combined. Following addition of concentrated H2SO4 (1 mL), the solution was heated to 90° C. for 30 min and cooled to ambient temperature. The reaction was slowly diluted with DI water (30 mL, potential exotherm). The reaction mixture was partitioned between CH2Cl2 (150 mL) and water (150 mL). The organic phase was washed with DI water, 10% NaHCO3 (aq), brine (150 mL), and then was dried (MgSO4) and concentrated to a brown oil. The residue was purified by column chromatography (600 mL SiO2, 35% EtOAc/hexanes) to provide the desired product (3.25 g) as a pale yellow oil. 1H NMR (400 MHz, CDCl3) δ 7.33-7.20 (m, 5H), 3.72 (s, 3H), 3.47 (s, 2H), 3.08-2.96 (m, 4H), 2.24 (s, 3H); MS (EI+) 260 (M+H).

1. temperaturecooled to ambient temperature
2. customThe reaction mixture was partitioned between CH2Cl2 (150 mL) and water (150 mL)
3. washThe organic phase was washed with DI water, 10% NaHCO3 (aq), brine (150 mL)
4. dry with materialwas dried (MgSO4)
5. concentrationconcentrated to a brown oil
6. customThe residue was purified by column chromatography (600 mL SiO2, 35% EtOAc/hexanes)

ORD record

ord-3413087edbb4491a8e88a1db9826a0a6

Source dataset

uspto-grants-2007_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07282501B2