HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxybenzaldehyde → 2-Bromo-5-hydroxybenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxybenzaldehyde | HCID 101 | — |
| Reactant | Bromine | HCID 24408 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Bromo-5-hydroxybenzaldehyde | HCID 387179 | 63.7% |
Reaction Steps
To a suspension of 3-hydroxybenzaldehyde (1 kg, 8.2 mol) in CH2Cl2 (10 L) was added a solution of bromine (1.3 kg, 8.2 mol) in CH2Cl2 (620 mL) over 1 h. After stirring for about 22 h, the solids were isolated by filtration, washed with CH2Cl2 (4 L), and dried under vacuum to afford of 2-bromo-5-hydroxybenzaldehyde as a tan solid (1.05 kg, 63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07282501B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-af67694d474546d6825e80924afe9f47 |
| Source note | uspto-grants-2007_10 |