HCID 17984522, compound → HCID 17984526, compound

HRID 1181060Notes

Reaction equation

HRID 1181060 reaction equation
C([O:5][C:6](=[O:24])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][C:10]=1[CH:16]([C:18]([O:20][CH:21]([CH3:23])[CH3:22])=[O:19])[NH2:17])(C)(C)C.[C:25]1([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH:30]=[CH:29][C:28]([C:31]2[CH:35]=[C:34]([CH3:36])[N:33]([CH2:37][CH2:38]O)[N:32]=2)=[CH:27][CH:26]=1>>[C:25]1([C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH:30]=[CH:29][C:28]([C:31]2[CH:35]=[C:34]([CH3:36])[N:33]([CH2:37][CH2:38][O:15][C:12]3[CH:13]=[CH:14][C:9]([CH2:8][CH2:7][C:6]([OH:5])=[O:24])=[C:10]([CH:16]([C:18]([O:20][CH:21]([CH3:22])[CH3:23])=[O:19])[NH2:17])[CH:11]=3)[N:32]=2)=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 17984522HCID 17984522, compoundHCID 68746260HCID 68746260, compound

Product 1

HCID 17984526HCID 17984526, compound

Procedure

The title compound was prepared from 3-[4-hydroxy-2-(isopropoxycarbonyl-amino-methyl)-phenyl]-propionic acid tert-butyl ester (Prep 16) and 2-(3-biphenyl-4-yl-5-methyl-pyrazol-1-yl)-ethanol (Prep 11) using Standard coupling procedure B followed by Standard hydrolysis procedure C. MS [ES] m/e 542 (M+1)+.

Workup

  1. customfollowed by Standard hydrolysis procedure C

Sources & evidence

ORD record
ord-660f01be45b242b48101f5d5656df70a
Source dataset
uspto-grants-2007_10
Patent number
US07282501B2

Reaction notes

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