Toluene-4-sulfonic acid 2-(2-biphenyl-4-yl-methyl-oxazol-4-yl)ethyl ester → 3-[4-[2-(2-Biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid methyl ester

HRID 1181078Notes

Reaction equation

HRID 1181078 reaction equation
[CH3:1][O:2][C:3](=[O:21])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=1[CH2:13][NH:14][C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16].[C:22]1([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)[CH:27]=[CH:26][C:25]([C:28]2[O:29][C:30]([CH3:46])=[C:31]([CH2:33][CH2:34]OS(C3C=CC(C)=CC=3)(=O)=O)[N:32]=2)=[CH:24][CH:23]=1>>[CH3:1][O:2][C:3](=[O:21])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:34][CH2:33][C:31]2[N:32]=[C:28]([C:25]3[CH:26]=[CH:27][C:22]([C:47]4[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=4)=[CH:23][CH:24]=3)[O:29][C:30]=2[CH3:46])=[CH:8][C:7]=1[CH2:13][NH:14][C:15]([O:17][CH:18]([CH3:19])[CH3:20])=[O:16]

Participants

3

Reactant 2

HCID 12966835Toluene-4-sulfonic acid 2-(2-biphenyl-4-yl-methyl-oxazol-4-yl)ethyl esterHCID 589789623-[4-Hydroxy-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid methyl ester

Product 1

HCID 589792543-[4-[2-(2-Biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid methyl ester

Procedure

3-[4-Hydroxy-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid methyl ester (Preparation 17) and toluene-4-sulfonic acid 2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)ethyl ester (Preparation 1) were combined according to Standard procedure A to give the title compound.

Sources & evidence

ORD record
ord-276074cc22604498bec28e7a14e99460
Source dataset
uspto-grants-2007_10
Patent number
US07282501B2

Reaction notes

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