反应详情

A solution of nitromethane (2.02 mL, 37.3 mmol) in ethanol (10 mL) was treated with 10N NaOH (3.0 mL) at ambient temperature. A white solid precipitated immediately, and a solution of 5-benzyloxy-2-bromo-benzaldehyde (8.67 g, 29.8 mmol) in CH2Cl2 (50 mL) was added. The reaction mixture was stirred for 18 h and quenched with water (100 mL). The mixture was extracted with CH2Cl2 (2×50 mL), dried (Na2SO4), and concentrated to a residue, which was then purified by silica gel chromatography (hexanes/EtOAc 8/2) to afford 1-(5-benzyloxy-2-bromo-phenyl)-2-nitro-ethanol as yellow oil.

1. customA white solid precipitated immediately
2. customquenched with water (100 mL)
3. extractionThe mixture was extracted with CH2Cl2 (2×50 mL)
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated to a residue, which
6. customwas then purified by silica gel chromatography (hexanes/EtOAc 8/2)