反应详情

General procedure for the parallel synthesis of analogs using the DynaVac Carousel apparatus: A 50 mL glass tube with screw cap and nitrogen inlet was charged with 3-(2-benzyloxymethyl-4-hydroxy-phenyl)-propionic acid tert-butyl ester (0.050 g, 0.146 mmol), toluene-4-sulfonic acid 2-(2-biphenyl-4-yl-5-methyloxazol-4-yl)ethyl ester (0.078 g, 0.18 mmol), anhydrous DMF (0.5 mL), and then cesium carbonate (0.072 g, 0.22 mmol). The mixture was stirred at ambient temperature for 16 h. MS analysis of the reaction indicated that the intermediate ester was formed, MS (ES) m/e 534 (M+1). The crude reaction was poured into ether (30 mL), and washed with brine (2×), dried (Na2SO4), and concentrated in vacuo. The crude residue was dissolved in CH2Cl2 (2 mL) and trifluoroacetic acid was added (1.0 mL). The reaction mixture was stirred at ambient temperature for 2 h and was concentrated under a stream of N2. The crude product was purified by mass-directed reverse phase HPLC to provide 0.053 g (71%) of 3-{4-[2-(2-Cyclohexyl-5-methyloxazol-4-yl)ethoxy]-2-phenoxymethylphenyl}propionic acid. MS (ES) m/e 478 (M+1).

1. customGeneral procedure for the parallel synthesis of analogs
2. customA 50 mL glass tube with screw cap
3. customwas formed
4. customThe crude reaction
5. washwashed with brine (2×)
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated in vacuo
8. dissolutionThe crude residue was dissolved in CH2Cl2 (2 mL)
9. additiontrifluoroacetic acid was added (1.0 mL)
10. stirringThe reaction mixture was stirred at ambient temperature for 2 h
11. concentrationwas concentrated under a stream of N2
12. customThe crude product was purified by mass-directed reverse phase HPLC